GAMBARAN HISTOPATOLOGI KULIT MENCIT PUTIH (Mus musculus) SETELAH DIBERI PAPARAN ASAP PEMBAKARAN

Abstract

ABSTRACT
Forest fire commonly becomes a problem throughout the world. Its smoke contains a great
amount of gas like carbon monoxide (CO), nitrogen dioxide (NO2), particulate matter (PM),
and volatile organic compounds (VOCs) which consist of formaldehyde, benzene, and
acrolein released to the atmosphere, sulfur dioxide (SO2), and Ozone (O2). The smoke can
also cause skin disorder. The object of this research was to find out the influence of the
smoke of organic burning on the histophatological description in the skin of mice (Mus
musculus) within 7 days and 14 days. The research used 18 white male mice that were 2-3
days with the duration of 10 minutes/day. Control (C) was not given the smoke exposure. The
period of smoke exposure in the treatment 1 (T1) was 7 days and in the treatment 2 (T2) was
14 days. The changes in the skin thickening and the accumulation of inflammation cells were
assessed by using a microscope. The result of the research showed that C = 8.3 μm; T1 =
13.8 μm; T2 = 16.8 μm and there was no accumulation of inflammation cell infiltration in the
control, while there was the accumulation of inflammation cell infiltration in T1 and in T2.
The conclusion of the research was that there were the changes in histophatological
description in the skin of white mice (Mus musculus) after they were exposed with smoke.
Keywords: Accumulation of Inflammation Cells, Forest Fire, Mice’s Skin Thickening